Calcium signaling and gene regulation

We investigate ion-channel function and its role in signal transduction and gene regulation. Our research focuses on the molecular mechanism of store-operated calcium channels, which play central roles in immune function. We combine functional live cell techniques, including electrophysiology and fluorescence microscopy in combination with mutagenesis studies to determine the structure and mechanism of Ca²⁺ signalling complexes. We collaborate with computer scientist to determine channel regulation via molecular dynamics simulations. Current funded project aims to determine how transcription factor activation is precisely controlled in temporal and spatial shaped calcium microdomains of single living cells.

FWF project P32778 (2020 – 2023)

FWF project P28701 (2015 – 2020)

Contact:

rainer.schindl@medunigraz.at